Title : Low serum total nitrite and nitrate levels in severe leptospirosis
نویسندگان
چکیده
Title: Low serum total nitrite and nitrate levels in severe leptospirosis Authors Thilini Kalugalage, Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka. Email: [email protected] Chaturaka Rodrigo, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Email: [email protected] Thamal Vithanage, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Email: [email protected] Pranitha Somaratne, Medical Research Institute, Colombo, Sri Lanka. Email: [email protected] H. Janaka De Silva, Department of Medicine, Faculty of Medicine, University of Kelaniya, Sri Lanka. Email: [email protected] Shiroma Handunnetti, Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka. Email: [email protected] Senaka Rajapakse, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Email: [email protected]
منابع مشابه
Low serum total nitrite and nitrate levels in severe leptospirosis
BACKGROUND The relationship between inducible nitric oxide synthatase activity and disease severity in leptospirosis is unclear. Nitric oxide is converted to nitrites and nitrates, thus nitrite and nitrate levels (NOx) in serum are considered surrogate markers for nitric oxide. NOx are excreted through the kidneys, and elimination is diminished in renal impairment. We assessed the correlation o...
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Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...
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